منابع مشابه
High LET heavy ion radiation induces p53-independent apoptosis.
Conventional clinical treatments with X-rays provide an effective modality for widely various human cancers, however, therapeutic results are sometimes poor. Many mutations have been reported to be in the p53 gene in advanced human cancers. The p53 plays a pivotal role in the pathway which controls apoptosis, cell growth and cell proliferation, and mutations or deletions in the p53 gene lead to...
متن کاملThe PTB Focused Microbeam for High - and Low - LET Radiation
Melvyn Folkard, Gray Cancer Institute, UK Barry D. Michael, Gray Cancer Institute, UK Kevin M. Prise, Gray Cancer Institute, UK Aloke Chatterjee, Lawrence Berkeley National Laboratory, Berkeley, CA Leslie Braby, Texas A&M University, College Station, TX David Brenner, Columbia University, New York, NY Roberto Cherubini, INFN, Legnaro, Italy Dieter Frankenberg, Göttingen, Germany Mark Hill, MRC,...
متن کاملDoes Hze Radiation-induced Dna Damage Differ from Low-energy High Let Radiation Damage?
METHODS We have used 1 GeV/u and 600 MeV/u iron ions at NSRL, 300 kVp X-rays and 25 MeV/u nitrogen ions from the 88” cyclotron at Lawrence Berkeley National Laboratory. For measurements of DNA double-strand breaks we are using pulsed-field gel electrophoresis (PFGE) with a dual label technique that includes control samples in each lane and the use of the most sensitive part of the FAR vs dose c...
متن کاملOncogenes and radiation carcinogenesis.
Current research indicates a role for several oncogenes in radiation-induced carcinogenesis in vivo and cell transformation in vitro. Certain oncogenes are probably also involved in some cases of human cancer caused by exposure to nonionizing radiation and may play a mechanistic role in the phenomenon of radioresistance seen in later stages of tumor progression. The mechanisms of oncogene activ...
متن کاملRisk of Radiation Carcinogenesis
Occupational radiation exposure from the space environment may increase cancer morbidity or mortality risk in astronauts. This risk may be influenced by other space fl ight factors including microgravity and e nvironmental contaminants. A Mars mission will not be fe asible unless improved shielding is developed or transit time is decreased. – Human Research Program Requirements Document, HRP-47...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiation Research
سال: 1985
ISSN: 0033-7587
DOI: 10.2307/3576646